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Residing in an eerie hilltop mansion are Dr. Maria Frankenstein and her brother Rudolph, conducting the same bizarre and deadly artificial brain transplant experiments that forced them to flee their European homeland. In a nearby town, the legendary Jesse James and his companion, Hank Tracy, are caught in a gunfight that leaves Hank seriously wounded. Jesse brings back the only nearby doctor... the sinister Maria Frankenstein. Hank will be the perfect subject for her next experiment and Jesse the perfect target of her romantic desires. She successfully transplants an artificial brain into the skull of Hank, transforming him into a monstrous creature named Igor...